| Flumazenil(Adult) | 0.2 mg IV push over 15 seconds | 0.2 mg after 45 seconds of initial dose, up to maximum dose of 1 mg | 1 – 2 (peak: within 6 – 10) |
30 – 60 | Duration of most benzodiazepines greatly exceeds the duration of flumazenil, therefore careful monitoring must continue for 1 hour after reversal is initiated.
Re-sedation may be treated after 20 minutes at a dose of 1 mg given in 0.2 mg/min increments until desired effect is achieved. No more than 3 mg in any 1hour period.
Should be avoided in patients with seizure disorder or who are chronically maintained on
benzodiazepines.
Support airway and breathing using bag-mask ventilation with 100 % inspired oxygen until flumazenil is administered.
|
| Flumazenil(Pediatric) | 0.01 mg/kg (maximum dose: 0.2 mg) IV push over 15 seconds |
0.01 mg/kg (maximum dose: 0.2 mg) after 45 seconds of initial dose, up to maximum dose of 0.05 mg/kg or 1 mg (whichever is lower) |
1 – 2 (peak: within 6 – 10)
|
30 – 60
|
Same as above |
| Naloxone (Adult) | 0.1 – 0.4 mg IV | 0.1 – 0.2 mg repeated every 2 – 3 minutes | 2 – 3 | Depends on the dose and route of administration | Duration of the opioid may exceed that of naloxone, therefore repeated doses may be necessary.
Support airway and breathing using bag-mask ventilation with 100 % inspired oxygen until naloxone is administered.
|
| Naloxone(Pediatric) | Children <20 kg: 0.1 mg /kg IV or IO (maximum 2 mg per dose)
Children over 20 kg: 2 mg IV or IO | Repeat every 1 – 2 minutes (maximum total dose of 10 mg) | 2 – 3 | Depends on the dose and route of administration | Same as above |
