TIOTROPIUM BROMIDE MONOHYDRATE (18 mcg capsule for inhalation)

Download PDF : TIOTROPIUM BROMIDE MONOHYDRATE (18 mcg capsule for inhalation)

1. Indication:

Chronic obstructive pulmonary disease, maintenance.

2. Instruction to use (How is this drug best taken):

• Dry powder inhaler: Do not swallow capsule. Administer at the same time each day. Do not remove capsule from blister until immediately before use.
• Place capsule in the center chamber of the HandiHaler Inhaler.
• Close mouthpiece firmly until a click is heard, leaving dustcap open.
• The capsule is pierced by pressing and releasing the green piercing button on the side of the HandiHaler device.
• Exhale fully, then Close lips tightly around mouthpiece; do not exhale into inhaler.
• Tilt head slightly back and inhale (rapidly, steadily, and deeply); the capsule vibration (rattle) may be heard within the device.
• Hold breath for a few seconds then repeat inhalation procedure using the same tiotropium capsule.
• Do not pierce the capsule a second time.
• Throw away empty capsule by tipping into a trash can without touching it; do not leave in inhaler.
• Keep capsules and inhaler dry.
• Discard any capsules that are exposed to air and not used immediately.

3. Warnings

• Bronchospasm: discontinue use and consider other therapy if bronchospasm occurs.
• CNS effects: May cause dizziness and blurred vision
• Hypersensitivity reactions: Immediate hypersensitivity reactions (urticaria, angioedema, rash, bronchospasm, anaphylaxis, itching) have been reported. Discontinue immediately if signs/symptoms occur. Use with caution in patients with a history of hypersensitivity to atropine.

4. Side effects

May include cough, dry mouth, constipation, urinary retention, pharyngitis, sinusitis, and respiratory tract infections.

5. Precautions

• This drug is not indicated for acute bronchospasm (rescue therapy)
• Report symptoms of acute narrow-angle glaucoma (eye pain or discomfort, blurred vision, visual halos)

Link: video administration method: